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Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Subversion of cell cycle regulatory pathways.

V Sanchez1, D H Spector

  • 1Deaprtment of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, College Station, TX 77843-1266, USA.

Current Topics in Microbiology and Immunology
|July 22, 2008
PubMed
Summary
This summary is machine-generated.

Human cytomegalovirus (HCMV) hijacks host cell cycles to boost viral DNA production, overriding normal cell functions. This manipulation prevents cell death and ensures sufficient time for new virus assembly.

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Last Updated: Jul 3, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Human cytomegalovirus (HCMV) is a widespread herpesvirus with sophisticated mechanisms to ensure its replication.
  • Effective viral replication relies on manipulating host cell machinery.

Purpose of the Study:

  • To elucidate the strategies employed by HCMV to control host cell cycle progression.
  • To understand how HCMV prioritizes viral DNA synthesis over cellular DNA synthesis.

Main Methods:

  • Analysis of host cell cycle markers during HCMV infection.
  • Investigation of viral protein interactions with cell cycle regulators.
  • Assessment of cell cycle checkpoint activation and apoptosis pathways.

Main Results:

  • HCMV actively manipulates host cell cycle pathways early in infection.
  • Viral DNA replication is stimulated at the expense of host cellular DNA synthesis.
  • HCMV bypasses critical cell cycle checkpoints, inhibiting apoptosis.

Conclusions:

  • HCMV employs intricate cell cycle control mechanisms to promote viral progeny production.
  • Disruption of cell cycle checkpoints by HCMV is crucial for viral replication and survival.