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Related Experiment Video

Updated: Jul 3, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

In perspective: murine models of scleroderma.

Minghua Wu1, John Varga

  • 1Section of Rheumatology, Northwestern University Feinberg School of Medicine, 240 East Huron Street, Chicago, IL 60611, USA.

Current Rheumatology Reports
|July 22, 2008
PubMed
Summary

Developing animal models for systemic sclerosis (SSc) is crucial for understanding its complex pathogenesis. Current murine models offer insights into autoimmunity, vasculopathy, and fibrosis, aiding therapeutic target identification.

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Area of Science:

  • Immunology
  • Pathology
  • Genetics

Background:

  • Systemic sclerosis (SSc) pathogenesis is complex and poorly understood.
  • A lack of suitable animal models hinders research into SSc's key features: autoimmunity, vasculopathy, and fibrosis.

Purpose of the Study:

  • To review recent advancements in SSc murine models.
  • To analyze the strengths and limitations of existing SSc models.
  • To discuss their utility in identifying therapeutic targets.

Main Methods:

  • Experimental manipulation of inbred murine strains.
  • Genetic engineering of novel murine strains.
  • Application of high-throughput discovery technologies (e.g., DNA microarrays).

Main Results:

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Last Updated: Jul 3, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Published on: November 1, 2015

Murine Model of Epicutaneously-Induced Immunomodulation
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Murine Model of Epicutaneously-Induced Immunomodulation

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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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  • Murine models can mimic SSc fibrosis through experimental manipulation.
  • Genetically engineered mice exhibit spontaneous fibrosis or protection from it.
  • High-throughput technologies identify novel genes and regulatory networks involved in SSc.

Conclusions:

  • Progress in understanding SSc pathogenesis is linked to the development of effective murine models.
  • These models are vital for elucidating cellular and molecular mechanisms of SSc.
  • Insights from these models can guide the development of novel SSc therapies.