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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Published on: October 8, 2016

Circulating progenitor cells and scleroderma.

Richard H Gomer1

  • 1Department of Biochemistry and Cell Biology, MS-140, Rice University, 6100 South Main Street, Houston, TX 77005, USA. richard@rice.edu

Current Rheumatology Reports
|July 22, 2008
PubMed
Summary
This summary is machine-generated.

Scleroderma involves tissue damage due to poor blood vessel formation. Research suggests defects in circulating progenitor cells contribute to this, offering potential new therapeutic targets for systemic sclerosis.

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Last Updated: Jul 3, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Isolation of Blood-vessel-derived Multipotent Precursors from Human Skeletal Muscle
10:52

Isolation of Blood-vessel-derived Multipotent Precursors from Human Skeletal Muscle

Published on: August 21, 2014

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells
10:16

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells

Published on: June 14, 2017

Area of Science:

  • Vascular Biology
  • Fibrosis Research
  • Regenerative Medicine

Background:

  • Scleroderma (systemic sclerosis) is a complex disease characterized by tissue ischemia and fibrosis in various organs.
  • Tissue ischemia in scleroderma stems from impaired blood vessel function and neovascularization.
  • Circulating endothelial progenitor cells are crucial for blood vessel repair, but their role in scleroderma is unclear.

Purpose of the Study:

  • To investigate the number and function of circulating endothelial progenitor cells in scleroderma patients.
  • To explore the potential involvement of fibrocytes in scleroderma pathogenesis.
  • To identify novel therapeutic strategies targeting circulating progenitor cells for scleroderma treatment.

Main Methods:

  • Analysis of circulating endothelial progenitor cell populations in scleroderma patients.
  • Assessment of endothelial progenitor cell function related to neovascularization.
  • Investigation of fibrocytes differentiation and contribution to fibrosis.

Main Results:

  • Scleroderma patients exhibit quantitative and functional deficits in circulating endothelial progenitor cells.
  • Evidence suggests fibrocytes, derived from distinct bone marrow progenitors, are implicated in fibrotic processes.
  • Tissue ischemia and subsequent fibrosis appear linked to progenitor cell dysfunction.

Conclusions:

  • Defects in circulating progenitor cells, including endothelial progenitor cells and fibrocytes, are central to scleroderma pathophysiology.
  • Targeting the production, function, and differentiation of these progenitor cells presents a promising avenue for scleroderma therapy.