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Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

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Related Experiment Video

Updated: Jul 3, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Scleroderma gene expression and pathway signatures.

Jennifer L Sargent1, Ausra Milano, M K Connolly

  • 1Department of Genetics, Dartmouth Medical School, 7400 Remsen, Hanover, NH 03755, USA.

Current Rheumatology Reports
|July 22, 2008
PubMed
Summary
This summary is machine-generated.

Gene expression in scleroderma reveals significant changes in tissues, reflecting disease processes and patient heterogeneity. These signatures may identify biomarkers for disease activity and clinical outcomes.

Related Experiment Videos

Last Updated: Jul 3, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

  • Immunology
  • Genomics
  • Rheumatology

Background:

  • Scleroderma (systemic sclerosis) is characterized by significant alterations in gene expression within affected tissues.
  • These molecular changes are associated with lymphocyte infiltration and deregulation of biological pathways implicated in disease pathogenesis.
  • Gene expression patterns in scleroderma correlate with the clinical diversity observed among patients.

Purpose of the Study:

  • To analyze gene expression signatures in scleroderma to understand disease mechanisms.
  • To explore the potential of gene expression data for patient stratification and biomarker discovery.
  • To identify deregulated pathways contributing to the pathogenesis of scleroderma.

Main Methods:

  • Analysis of gene expression profiles from end-target tissues in patients with scleroderma.
  • Correlation of gene expression signatures with clinical heterogeneity and disease activity.
  • Identification of gene groups potentially serving as biomarkers.

Main Results:

  • Consistent and substantial changes in gene expression were observed in scleroderma end-target tissues.
  • Gene expression signatures reflect the clinical heterogeneity of scleroderma, enabling patient categorization.
  • Specific gene groups within these signatures show potential as biomarkers for clinical endpoints and disease activity.

Conclusions:

  • Gene expression profiling provides insights into the molecular mechanisms underlying scleroderma pathogenesis.
  • Mechanism-derived gene expression signatures can aid in understanding deregulated pathways in scleroderma.
  • Biomarkers derived from gene expression signatures may improve the management of scleroderma by predicting clinical outcomes and disease activity.