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Updated: Jul 3, 2026

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
Published on: August 20, 2007
De novo autoimmunity after organ transplantation: targets and possible pathways
Peter Boros1, Jonathan S Bromberg
1Recanati/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY, USA.
Abstract:
The development of autoantibodies to different tissue-specific antigens in patients without existing history of autoimmune diseases suggests that autoimmunity may develop de novo after organ transplantation. In addition to allo-specific immune responses, tissue-specific autoimmunity also appears contribute to the host anti-graft response, and thus may affect long-term graft function. As graft failure caused by chronic rejection is a major challenge in clinical transplantation, understanding de novo autoreactivity after transplantation has important ramifications. This review investigates this emerging concept by discussing target antigens and possible pathways.
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