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Updated: Jul 3, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Normal perfusion pressure hyperperfusion in cerebral arteriovenous malformation surgery: model study on the
S Nagasawa1, M Kawanishi, S Kondoh
1Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan.
Abstract:
A simulation study was undertaken using a compartmental flow model of a large high-flow cerebral arteriovenous malformation to investigate the hemodynamic changes during obliteration procedures. Under certain autoregulatory conditions, marked hyperperfusion (92 ml/100 g/min) could be induced in association with increased wall stress of the arterioles. Narrowing of the autoregulatory pressure range and its shift to a low pressure level are suspected to be among the possible causes of normal perfusion pressure breakthrough phenomenon.
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