Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell Signaling in Plants

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...

Defenses Against Pathogens and Herbivores

Defenses Against Pathogens and Herbivores

Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.

Microbe-Plant Interactions

Microbe-Plant Interactions

Microbe-plant interactions represent a dynamic spectrum of associations shaped by intricate chemical signaling. These interactions can be neutral, beneficial, or detrimental, and profoundly influence plant physiology, growth, and ecosystem function. The plant microbiome, comprising bacteria, fungi, archaea, protists, and viruses, plays a pivotal role in mediating these effects through surface colonization, internal colonization, or systemic symbiosis.Mutualistic associations, particularly with...

The Roles of Bacteria and Fungi in Plant Nutrition

The Roles of Bacteria and Fungi in Plant Nutrition

Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.

Plant Tissues

Plant Tissues

Plants are multicellular eukaryotes with tissue systems made of various cell types that carry out specific functions. Different tissues work together to perform a unique function and form an organ. Organs working together form organ systems. Vascular plants have two distinct organ systems: a shoot system and a root system. The shoot system consists of two portions: the vegetative (non-reproductive) parts of the plant, such as the leaves and the stems, and the reproductive parts of the plant,...

Introduction to Plant Diversity

Introduction to Plant Diversity

From Water to Land

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessment of the Prevalence of Angiostrongylus cantonensis Infection in Gastropods of Puerto Rico.

The American journal of tropical medicine and hygiene·2026

Same author

A new species of alien land flatworm in the Southern United States.

PeerJ·2024

Same author

Investigating Cellulose Binding of Peptides Derived from Carbohydrate Binding Module 1.

Biomacromolecules·2024

Same author

Cell consciousness: a dissenting opinion : The cellular basis of consciousness theory lacks empirical evidence for its claims that all cells have consciousness.

EMBO reports·2024

Same author

Does the KDEL receptor cycle between the Golgi and the ER?

Nature communications·2024

Same author

Make It Shine: Labelling the ER for Light and Fluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2024

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

BFA effects are tissue and not just plant specific.

David G Robinson¹, Markus Langhans, Claude Saint-Jore-Dupas

¹Department of Cell Biology, Heidelberg Institute for Plant Sciences, University of Heidelberg, 69120 Heidelberg, Germany.

Trends in Plant Science

|July 22, 2008

Summary

Brefeldin A (BFA) drug research reveals its impact on secretion and endocytosis. Studies suggest BFA affects more than just its known molecular targets, influencing Golgi apparatus morphology in plants.

More Related Videos

Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana

Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana

Published on: May 29, 2010

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Published on: June 23, 2022

Related Experiment Videos

Last Updated: Jul 3, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana

Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana

Published on: May 29, 2010

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Published on: June 23, 2022

Area of Science:

Plant cell biology
Molecular biology
Cellular transport

Background:

Brefeldin A (BFA) is a widely used drug in cell biology research.
It is known to interfere with vesicle coat proteins, impacting secretion and endocytosis pathways.
BFA acts on guanine nucleotide exchange factors, disrupting cellular processes.

Purpose of the Study:

To explore the broader effects of Brefeldin A (BFA) beyond its primary molecular targets.
To investigate the morphological changes induced by BFA in the Golgi apparatus of various plant tissues.
To understand the comprehensive impact of BFA on plant cellular functions.

Main Methods:

Utilized Brefeldin A (BFA) in diverse plant tissue models.
Observed and documented morphological alterations in the Golgi apparatus.
Analyzed cellular responses to BFA treatment.

Main Results:

Brefeldin A (BFA) induced significant morphological changes in the Golgi apparatus across multiple plant tissues.
The observed effects suggest a wider range of cellular interactions than previously identified.
These findings indicate BFA's influence extends beyond its direct molecular targets.

Conclusions:

Brefeldin A (BFA) exhibits a more complex role in cellular processes than currently understood.
Further research is warranted to elucidate the full spectrum of BFA's molecular and morphological impacts.
Understanding these broader effects is crucial for accurate interpretation of BFA-based experimental data in plant science.