Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same author

Toward a unifying mechanistic model of eukaryotic translation initiation through integrative single-molecule, structural, and computational insights.

Current opinion in structural biology·2026
Same author

Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A cascade of structural rearrangements positions peptide release factor 2 for polypeptide hydrolysis on the ribosome.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting.

Nature communications·2025
Same author

RNA adapts its flexibility to efficiently fold and resist unfolding.

Nucleic acids research·2025
Same journal

Allosteric disordering of eIF2B regulates the integrated stress response.

Nature chemical biology·2026
Same journal

A tail of two ligases.

Nature chemical biology·2026
Same journal

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Nature chemical biology·2026
Same journal

Image-guided activation of drugs with electromagnetic radiation.

Nature chemical biology·2026
Same journal

Detecting protein fluctuations at scale.

Nature chemical biology·2026
Same journal

Revealing the Wnt signalosome.

Nature chemical biology·2026
See all related articles

Related Experiment Video

Updated: Jul 3, 2026

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

Navigating the RNA folding landscape.

Ruben L Gonzalez

    Nature Chemical Biology
    |July 22, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Cooperative interactions drive RNA folding into its active form, similar to proteins. This research provides a foundation for studying the physical rules governing large RNA enzyme assembly.

    More Related Videos

    Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
    11:32

    Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

    Published on: May 24, 2017

    Comparative RNA Structure Analysis of Nascent and Mature Transcripts in Saccharomyces cerevisiae
    09:12

    Comparative RNA Structure Analysis of Nascent and Mature Transcripts in Saccharomyces cerevisiae

    Published on: February 27, 2026

    Related Experiment Videos

    Last Updated: Jul 3, 2026

    Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
    10:34

    Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

    Published on: December 9, 2022

    Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
    11:32

    Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

    Published on: May 24, 2017

    Comparative RNA Structure Analysis of Nascent and Mature Transcripts in Saccharomyces cerevisiae
    09:12

    Comparative RNA Structure Analysis of Nascent and Mature Transcripts in Saccharomyces cerevisiae

    Published on: February 27, 2026

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Structural Biology

    Background:

    • RNA molecules fold into specific three-dimensional structures to perform biological functions.
    • Understanding the physical principles governing RNA folding is crucial for comprehending RNA-based biological processes.

    Discussion:

    • Cooperative interactions, analogous to those in protein folding, are identified as key drivers in RNA folding.
    • These interactions guide RNA towards its biologically active, native conformation.
    • The study highlights the importance of physical principles in RNA structural biology.

    Key Insights:

    • Individual RNA folding reactions demonstrate that cooperative interactions are essential for achieving the native state.
    • This finding parallels the established mechanisms of protein folding.
    • The research provides a new perspective on RNA structural dynamics.

    Outlook:

    • The established platform facilitates future investigations into the physical principles of large RNA enzyme assembly.
    • Further research can explore the role of specific cooperative interactions in different RNA systems.
    • This work opens avenues for designing and engineering novel RNA-based catalysts.