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Updated: Jul 3, 2026
Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Selective hypothermia: an experimental study on traumatic brain injury in rats
Amylcar Edemilson Dvilevicius1, Mirto Nelso Prandini
1EPM, Universidade Federal de São Paulo, Brazil. amylcar@uol.com.br
Objective:
To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats.
Method:
After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through.
Results:
Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statistically significant.
Conclusion:
Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.
