Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Sulfur Assimilation01:20

Sulfur Assimilation

Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to become...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to the Letter to the Editor Regarding: "Predicting Postoperative Neurological Outcomes in Metastatic Spinal Tumor Surgery Using Machine Learning".

Spine·2026
Same author

Extent of intramedullary short tau inversion recovery signal change predicts traumatic cervical spinal cord injury outcomes in surgically treated older adults: a multicenter study in Japan.

Asian spine journal·2026
Same author

Analysis of Skeletal-Related Events in a Liaison Treatment for Metastatic Spinal Tumors: A 10-Year Retrospective Study.

Spine surgery and related research·2026
Same author

User Engagement and Demographics of a Medical Society-Led Website for Scoliosis: An Analysis using Google Analytics.

Spine surgery and related research·2026
Same author

Tree-based and sparse logistic models for predicting one-month postoperative performance status after surgery for spinal metastases.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Analysis of Skeletal-Related Events in a Liaison Treatment for Metastatic Spinal Tumors: A 10-Year Retrospective Study.

Spine surgery and related research·2026

Related Experiment Videos

SAPHO syndrome associated spondylitis.

Tomoyuki Takigawa1, Masato Tanaka, Kazuo Nakanishi

  • 1Department of Orthopaedic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama City, Okayama, 700-8558, Japan. takigawa2004@yahoo.co.jp

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
|July 22, 2008
PubMed
Summary

Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome spinal lesions often present chronically with slow progression. SAPHO syndrome with spinal involvement may be a subtype of seronegative spondyloarthropathy.

Related Experiment Videos

Area of Science:

  • Rheumatology
  • Dermatology
  • Orthopedics

Background:

  • The Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) syndrome is a rare autoinflammatory disorder.
  • While anterior chest involvement is common, the clinical course and classification of spinal SAPHO lesions remain unclear.

Purpose of the Study:

  • To elucidate the clinical course of spinal lesions in SAPHO syndrome.
  • To investigate the relationship between spinal SAPHO syndrome and seronegative spondyloarthropathies.

Main Methods:

  • Analysis of 13 patients diagnosed with spondylitis within the SAPHO syndrome spectrum.
  • Detailed review of clinical presentations, lesion progression, and associated dermatological findings.

Main Results:

  • Spinal lesions in SAPHO syndrome typically exhibit chronic onset with mild inflammation.
  • Lesions demonstrate slow progression, characterized by non-marginal syndesmophytes across multiple spinal levels.
  • Coexistence of characteristic skin lesions, particularly palmoplantar pustulosis, was noted.

Conclusions:

  • SAPHO syndrome with spinal involvement presents with distinct, slowly progressive radiographic features.
  • SAPHO syndrome, especially when associated with palmoplantar pustulosis, can be classified as a subtype of seronegative spondyloarthropathy.