Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incremental Prognostic Value of Subendocardial Myocardial Flow Reserve in Patients With Normal Perfusion.

Circulation·2026
Same author

In-Situ ssDNA Isolation from dsDNA Sources as a Streamlined Pathway to DNA Origami Assembly and Testing.

bioRxiv : the preprint server for biology·2026
Same author

Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men.

European heart journal·2026
Same author

Association of prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronary microvascular dysfunction: A pilot study.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2026
Same author

Prognostic Significance of Noninvasive Simultaneous Renal and Cardiac Perfusion: Interrogating Mechanisms of Cardiovascular-Kidney Interactions.

Circulation. Cardiovascular imaging·2026
Same author

Age- and Sex-Adjusted Myocardial Flow Reserve Percentiles for Personalized Cardiovascular Risk Assessment.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jul 3, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Immune modulation by melanoma-derived factors.

Dan Ilkovitch1, Diana M Lopez

  • 1Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, FL 33136, USA. dilkovitch@med.miami.edu

Experimental Dermatology
|July 23, 2008
PubMed
Summary

Melanoma immunotherapy shows promise, but antitumor immunity often fails due to immunosuppressive cells. Understanding these mechanisms is key to developing more effective melanoma treatments.

More Related Videos

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Related Experiment Videos

Last Updated: Jul 3, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Background:

  • Melanoma is an aggressive skin cancer with poor prognosis upon metastasis.
  • Melanomas are immunogenic, making them targets for immunotherapy with variable patient responses.
  • Understanding failed antitumor immunity is crucial for improving melanoma therapies.

Purpose of the Study:

  • To analyze antitumor immune responses in melanoma patients.
  • To uncover mechanisms blocking tumor-specific immune responses.
  • To identify new therapeutic targets for melanoma.

Main Methods:

  • Review of factors produced by melanomas that modulate suppressive mechanisms.
  • Description of the roles of immunosuppressive cells including dendritic cells, neutrophils, T-regulatory cells, myeloid-derived suppressor cells, and M2 macrophages.
  • Analysis of cell cross-talk and immunosuppression cycles in melanoma.

Main Results:

  • Immunosuppressive cell networks and factors significantly contribute to the failure of antitumor immune responses and therapies.
  • Melanoma-derived factors enhance suppressive mechanisms.
  • Specific immunosuppressive cells like immature dendritic cells, neutrophils, T-regulatory cells, myeloid-derived suppressor cells, and M2 macrophages play critical roles.

Conclusions:

  • Understanding the interplay of immunosuppressive cells is vital for future melanoma therapeutic strategies.
  • Targeting immunosuppressive networks offers potential for enhancing immunotherapy efficacy.
  • Further research into melanoma-associated immunosuppression is needed to overcome treatment resistance.