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Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Healing II: Complications01:24

Healing II: Complications

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Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Related Experiment Video

Updated: Jul 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Nodular scleroderma: a report of 2 cases.

Cooper C Wriston1, Adam I Rubin, Rosalie Elenitsas

  • 1Division of Dermatopathology, Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

The American Journal of Dermatopathology
|July 23, 2008
PubMed
Summary

Nodular scleroderma, a rare scleroderma variant, presents as keloidal nodules in affected skin areas. This report details two cases, highlighting key clinical and histological features for better recognition.

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Last Updated: Jul 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Nodular scleroderma is a rare scleroderma variant.
  • It can occur with systemic sclerosis or localized scleroderma.
  • Clinicians may lack familiarity with its features due to rarity.

Observation:

  • This disorder is clinically defined by keloidal nodules.
  • These nodules develop within sclerodermatous skin.
  • Histological examination may reveal keloidal collagen.

Findings:

  • Two cases of nodular scleroderma are presented.
  • The report focuses on clinical presentation and histological findings.
  • This aids in understanding a rare scleroderma variant.

Implications:

  • Increased awareness of nodular scleroderma's clinical and histological characteristics is needed.
  • Familiarity with this variant can improve diagnosis and patient management.
  • Further case reports may elucidate this rare condition.