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Updated: Jul 3, 2026

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
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Microchannel technologies for artificial lungs: (3) open rectangular channels.

J-K Lee1, M C Kung, H H Kung

  • 1Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 23, 2008
PubMed
Summary
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Researchers developed microchannel membranes for artificial lungs using lithography. These silicone rubber membranes show promising oxygen transfer, enhancing hemoglobin saturation in blood, with support-post designs offering design flexibility.

Area of Science:

  • Biomaterials Engineering
  • Medical Device Development
  • Respiratory Physiology

Background:

  • Artificial lungs are crucial for supporting patients with respiratory failure.
  • Developing efficient and scalable artificial lung technology remains a significant challenge.
  • Microfluidic devices offer potential for enhanced gas exchange in artificial lungs.

Purpose of the Study:

  • To fabricate and evaluate patterned silicone rubber membranes with microchannels for artificial lung applications.
  • To assess the oxygen transport capabilities of these microfabricated membranes using bovine blood.
  • To compare the performance of straight channel and support-post channel membrane designs.

Main Methods:

  • Lithographic techniques were employed to create silicone rubber membranes with 15-micrometer high microchannels.

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Last Updated: Jul 3, 2026

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Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
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Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

  • Two designs were tested: straight parallel channels and wide channels with support posts.
  • Experiments involved perfusing bovine blood (30% hematocrit) and measuring oxygen flux and hemoglobin saturation at varying residence times.

    • Main Results:

    • Average oxygen fluxes ranged from 1.1 x 10^-6 to 6.5 x 10^-7 moles/(min cm^2) with increasing residence time.
    • Hemoglobin saturation increased from 9% to 24% corresponding to the tested residence times.
    • Oxygen flux was found to be dependent on residence time due to transverse molecular diffusion and consistent across tested membranes.

    Conclusions:

    • Patterned silicone rubber microchannels demonstrate effective oxygen transfer for artificial lung applications.
    • Support-post channel designs are advantageous due to their scalability and reduced risk of blockage.
    • These microfabricated membranes represent a promising advancement in artificial lung technology.