Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spontaneous Haemothorax as Initial Presentation of Pleural Ewing Sarcoma: A Case Report.

Case reports in pulmonology·2026

Same author

Introducing a Sustainable Framework for Preschool Visual Acuity Screening: The Alexandroupolis Case.

Journal of clinical medicine·2026

Same author

Impact of Preservative-Free Travoprost on Intraocular Pressure and Ocular Surface in Primary Open-Angle Glaucoma Patients.

Life (Basel, Switzerland)·2025

Same author

Eyelid Radiotherapy-Treated Basal and Squamous Cell Carcinomas: A Case Series.

Acta medica (Hradec Kralove)·2025

Same author

CellOMaps: A compact representation for robust classification of lung adenocarcinoma growth patterns.

Computers in biology and medicine·2025

Same author

Implementing digital pathology: qualitative and financial insights from eight leading European laboratories.

Virchows Archiv : an international journal of pathology·2025

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Eyelid basal cell carcinoma with osteosarcomatous changes.

Aristeidis Konstantinidis¹, Yajati Ghosh, David Snead

¹Ophthalmology Department, Coventry & Warwickshire University Hospital, Coventry, United Kingdom. aristeidiskon@hotmail.com

Ophthalmic Plastic and Reconstructive Surgery

|July 23, 2008

Summary

A rare basal cell carcinoma with osteosarcomatous changes was found in an 80-year-old woman's eyelid. Surgical excision and reconstruction with a Hughes flap resulted in no recurrence after 10 months.

More Related Videos

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Related Experiment Videos

Last Updated: Jul 3, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Area of Science:

Ophthalmology
Dermatopathology
Surgical Oncology

Background:

Basal cell carcinoma (BCC) is the most common type of skin cancer.
Eyelid BCC can present unique challenges due to the delicate anatomical structures.
Metastatic or aggressive variants of BCC require specialized management.

Observation:

An 80-year-old female patient presented with a noticeable lump on her left lower eyelid.
Initial clinical presentation suggested a common eyelid lesion.

Findings:

Histopathological examination confirmed basal cell carcinoma with unusual osteosarcomatous differentiation.
Complete surgical excision of the tumor was performed.
Reconstruction of the eyelid defect was successfully achieved using a Hughes flap technique.

Implications:

This case highlights the importance of thorough histopathological evaluation for eyelid lesions, even those appearing common.
The successful use of a Hughes flap demonstrates its efficacy in managing complex eyelid defects after tumor excision.
Long-term surveillance is crucial for patients with aggressive BCC variants to monitor for recurrence.