Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting Soluble Adenylyl Cyclase for On-Demand Contraception.

Physiology (Bethesda, Md.)·2026
Same author

Regulatory role for tumor suppressor REST on estrogen receptor (ESR1) expression and leiomyoma pathophysiology.

The Journal of biological chemistry·2025
Same author

Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice.

PNAS nexus·2025
Same author

Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes.

Nature communications·2024
Same author

Estrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis.

bioRxiv : the preprint server for biology·2024
Same author

A tribute: David Lorn Garbers, PhD (1944-2006).

Molecular reproduction and development·2024
Same journal

RNA Modifications as Drug Targets: Unlocking the Therapeutic Potential of the Epitranscriptome.

Current genomics·2026
Same journal

AgriBioNER: A Named Entity Recognition Tool for Identification of ncRNA and Diseases in Agricultural Literature.

Current genomics·2026
Same journal

Understanding the Evolutionary Adaptations and the Associated Functional Dynamics of Diatom <i>Cyclotella Cryptica</i>: A Chloroplast Genome-wide Comparative Study.

Current genomics·2026
Same journal

The Role of Collagen Genetic Variability in Degenerative Disc Disease and Related Conditions.

Current genomics·2026
Same journal

Genomics-Driven Immunotherapy: Advancing Cancer Treatment through Personalized Approaches.

Current genomics·2026
Same journal

Innovative Applications and Challenges of Isothermal Amplification Technology in miRNA Detection.

Current genomics·2026
See all related articles

Related Experiment Video

Updated: Jul 3, 2026

Cost-Efficient Transcriptomic-Based Drug Screening
06:40

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Gene expression profiling and its practice in drug development.

Murty V Chengalvala1, Vargheese M Chennathukuzhi, Daniel S Johnston

  • 1ImmunoTechnologies, Covance Research Products, Denver, PA 17517, USA.

Current Genomics
|July 23, 2008
PubMed
Summary
This summary is machine-generated.

High-density DNA microarrays provide gene expression profiles, acting as genetic fingerprints. These profiles are crucial for understanding biological processes and advancing drug discovery by identifying new targets and predicting drug responses.

Keywords:
Expression profilingbiomarkersmicroarray analysispharmacogenomicstoxicogenomics

More Related Videos

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Related Experiment Videos

Last Updated: Jul 3, 2026

Cost-Efficient Transcriptomic-Based Drug Screening
06:40

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Area of Science:

  • Genomics
  • Systems Biology
  • Bioinformatics

Background:

  • Genome sequencing advancements necessitate new tools for biological data analysis.
  • Understanding gene expression is key to deciphering complex biological processes and physiological outcomes.

Purpose of the Study:

  • To review the application of gene expression profiling in biological research.
  • To highlight the role of DNA microarrays in generating functional genomic information.
  • To discuss the utility of these profiles in drug discovery and development.

Main Methods:

  • Utilizing high-density DNA microarrays for large-scale gene expression analysis.
  • Analyzing gene expression patterns across different tissues and experimental conditions.
  • Employing computational tools to interpret genomic data and predict gene function.

Main Results:

  • Gene expression profiles serve as genetic fingerprints, characterizing cells or tissues.
  • Microarray technologies generate vast datasets, driving the development of analytical tools.
  • These profiles are instrumental in identifying novel drug targets and understanding drug variability.

Conclusions:

  • Gene expression profiling is a powerful approach for biological investigation.
  • DNA microarrays significantly contribute to functional genomics and drug discovery.
  • Understanding gene expression patterns aids in predicting novel gene functions and individual drug responses.