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10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Normobaric and hyperbaric oxygen therapy for migraine and cluster headache
Michael H Bennett1, Christopher French, Alexander Schnabel
1Diving and Hyperbaric Medicine, Prince of Wales Hospital, Barker Street, Randwick, NSW, Australia, 2031. m.bennett@unsw.edu.au
The Cochrane Database of Systematic Reviews
|July 23, 2008
Summary
Hyperbaric oxygen therapy (HBOT) shows promise for acute migraine relief. Normobaric oxygen therapy (NBOT) offers weak evidence for cluster headache treatment, being safe and accessible.
Area of Science:
- Neurology
- Oxygen Therapy
Background:
- Migraine and cluster headaches are debilitating neurological conditions.
- Migraine impacts up to 18% of women; cluster headaches are rarer (0.2%).
- Various acute and prophylactic treatments exist.
Purpose of the Study:
- To evaluate the safety and efficacy of hyperbaric oxygen therapy (HBOT) and normobaric oxygen therapy (NBOT).
- To assess HBOT and NBOT for both acute treatment and prevention of migraine and cluster headaches.
Main Methods:
- Systematic review of randomized trials identified through extensive database searches (CENTRAL, MEDLINE, EMBASE, etc.) up to May 2008.
- Included trials compared HBOT or NBOT against sham interventions, other active treatments, or no treatment.
- Study quality and data extraction were performed independently by three reviewers.
Main Results:
- Nine trials with 201 participants were analyzed.
- HBOT demonstrated effectiveness in relieving acute migraine headaches compared to sham therapy (RR 5.97, P=0.01).
- NBOT showed effectiveness in terminating cluster headaches versus sham (RR 7.88, P=0.04), with a 76% patient response rate; HBOT showed a trend for cluster headache termination (P=0.08).
Conclusions:
- Limited evidence suggests HBOT is effective for acute migraine termination.
- Weak evidence indicates NBOT may be effective for cluster headaches.
- NBOT is a safe, inexpensive, and easily administered option for cluster headaches, warranting continued use despite limited trial data.
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