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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

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Related Experiment Video

Updated: Jul 3, 2026

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

Thyroid incidentalomas identified by 18F-FDG PET: sonographic correlation.

Jin Young Kwak1, Eun-Kyung Kim, Mijin Yun

  • 1Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, 250 Seongsanno (134 Sinchon-dong), Seodaemun-gu, Seoul 120-752, Korea.

AJR. American Journal of Roentgenology
|July 24, 2008
PubMed
Summary

Thyroid incidentalomas found on FDG PET scans have a high malignancy risk. Sonography effectively differentiates benign from malignant nodules, with suspicious findings indicating higher cancer probability.

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Last Updated: Jul 3, 2026

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
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Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Oncology

Background:

  • Thyroid incidentalomas are common findings on (18)F-FDG PET scans.
  • Evaluating the malignancy risk of these incidentalomas is crucial for patient management.

Purpose of the Study:

  • To assess the malignancy risk of thyroid incidentalomas detected by (18)F-FDG PET.
  • To determine the diagnostic accuracy of sonography in differentiating benign from malignant thyroid incidentalomas.

Main Methods:

  • Retrospective analysis of 87 focal thyroid lesions identified on (18)F-FDG PET and sonography.
  • Comparison of maximum Standardized Uptake Value (SUV) and sonographic features for malignancy differentiation.
  • Statistical analysis including kappa test and logistic regression.

Main Results:

  • Maximum SUV did not significantly differentiate between benign and malignant thyroid lesions.
  • Suspicious sonographic findings showed a 75.5% malignancy rate, while probably benign findings had a 13.2% malignancy rate.
  • Sonographic features were statistically significant in predicting malignancy (OR=26.2, p=0.001).

Conclusions:

  • Focal thyroid incidentalomas on (18)F-FDG PET have a substantial malignancy probability (48.3%).
  • Sonography is a valuable tool for risk stratification, with suspicious findings indicating a significantly higher likelihood of malignancy.
  • Maximum SUV is not a reliable indicator for differentiating benign from malignant thyroid incidentalomas.