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Updated: Jul 3, 2026
Understanding Cerebellar Pattern Formation
Published on: November 1, 2007
Dandy-Walker syndrome, associated anomalies and survival through infancy: a population-based study
Hamisu M Salihu1, Jennifer L Kornosky, Charlotte M Druschel
1Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA. hamisu.salihu@gmail.com
Objectives:
To assess infant mortality patterns associated with Dandy-Walker syndrome (DWS) and the impact of concomitant anomalies.
Methods:
Data for this study were obtained from the New York State Congenital Malformations Registry, an ongoing population-based validated surveillance system.
Results:
The 196 cases of DWS had a high infant mortality rate (250/1,000), and the elevated risk correlated positively with additional anomalies in a dose-effect pattern (p for trend <0.01). Infants with DWS and two or more affected organ systems were about 6 times as likely to die postneonatally than their counterparts with isolated DWS [adjusted hazards ratio (AHR) = 6.01; 95% CI = 1.52-24.21].
Conclusion:
This study confirms the widely held notion that DWS is a heterogeneous rather than a homogeneous entity as shown by the dissimilar infant survival patterns found.
