Related Experiment Video
Updated: Jul 3, 2026

Seven Steps to Stellate Cells
Published on: May 10, 2011
Oligopyridine ligands derived from amino acid precursors: their Zn2+ complexation and effects on hepatic stellate
Hiroshi Tsukube1, Yuki Noda, Yumiko Kataoka
1Department of Chemistry, Graduate School of Science, Osaka City University, Sugimoto, Osaka, 558-8585, Japan. tsukube@sci.osaka-cu.ac.jp
Abstract:
A series of oligopyridine ligands were derived from amino acid amides in which amide oxygen and ternary nitrogen atoms were combined with pyridine moieties. 1H NMR and circular dichroism spectroscopic characterizations revealed that they formed stable Zn2+ complexes in neutral aqueous solutions and caused Zn2+ deficiency in the hepatic stellate cell systems. Since collagen synthesis was effectively promoted in the cells, the present oligopyridine derivatives worked as biocompatible ligands for Zn2+ complexation and cell activation.
More Related Videos
06:31Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase
Published on: March 19, 2020
11:04Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
Published on: September 7, 2019
Related Concept Videos
Ligand Binding and Linkage
Complexometric Titration: Ligands
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Complexation Equilibria: The Chelate Effect
Ligand Binding Sites
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Complexation Equilibria: Factors Influencing Stability of Complexes