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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
Microenvironments01:22

Microenvironments

Microorganisms inhabit highly localized spaces known as microenvironments, which are defined by distinct physical and chemical characteristics. These include oxygen concentration, pH, temperature, light availability, and nutrient levels. The conditions within a microenvironment can differ markedly from those in the surrounding area and significantly influence microbial growth, metabolism, and community structure.Microenvironments often display sharp physicochemical gradients over small spatial...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Optimized Nuclei Isolation from Fresh and Frozen Solid Tumor Specimens for Multiome Sequencing
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Published on: October 13, 2023

Nuclear microenvironments and cancer.

Gary S Stein1, James R Davie, J Randy Knowlton

  • 1Department of Cell Biology, S3-310, University of Massachusetts Medical School, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. gary.stein@umassmed.edu

Journal of Cellular Biochemistry
|July 24, 2008
PubMed
Summary
This summary is machine-generated.

Nuclear organization of nucleic acids and proteins is vital for biological control. Disruptions in this machinery are linked to cancer, suggesting new diagnostic and therapeutic strategies.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Regulatory proteins and nucleic acids form organized nuclear microenvironments.
  • Compartmentalization of gene expression, replication, and repair machinery ensures biological control fidelity.

Purpose of the Study:

  • To explore the functional link between nuclear organization disruptions and tumorigenesis.
  • To highlight the potential of integrated biological approaches for cancer diagnostics and therapy.

Main Methods:

  • Utilized cellular, molecular, and biochemical approaches.
  • Employed in vivo genetic models.
  • Integrated structural biology, genomics, proteomics, and bioinformatics.

Main Results:

  • Demonstrated that perturbations in regulatory machinery organization are linked to cancer onset and progression.
  • Highlighted the importance of nuclear compartmentalization for biological control.

Conclusions:

  • The study underscores the critical role of nuclear architecture in preventing cancer.
  • Combined multi-omics and structural biology approaches offer promising avenues for novel cancer diagnostics and therapeutics.