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[Assessment of metabolic disturbances risk factors in urolithiasis children with questionnaire survey]
Insights
Metabolic disturbances leading to childhood urolithiasis are influenced by parental lifestyle, maternal health during pregnancy, and environmental factors. Immunogenetic and hereditary factors also play a role in triggering the condition.
Area of Science:
- Pediatric Nephrology
- Environmental Health
- Genetics
Context:
- Investigated risk factors for metabolic disturbances in 38 children (1.7-14 years) with urolithiasis.
- Utilized parental questionnaires to gather disease history and lifestyle information.
- Examined maternal health, including chronic diseases, pregnancy complications (toxicosis, gestosis), infections, and dietary habits.
Purpose:
- To identify key risk factors contributing to metabolic disturbances in children with urolithiasis.
- To explore the interplay between environmental, lifestyle, maternal, and genetic factors in pediatric urolithiasis.
- To understand the role of immunogenetic and hereditary mechanisms in the development of childhood urolithiasis.
Summary:
- Maternal chronic diseases and pregnancy complications were prevalent (72% mothers, 81.5% toxicosis/gestosis).
- Dietary adherence improved during pregnancy/lactation for 77% of mothers; breastfeeding duration varied.
- Mixed feeding from birth affected 23% of infants.
- Risk factors include environmental pollutants, parental lifestyle, maternal gynecological health, and intercurrent diseases.
Impact:
- Highlights the multifactorial nature of pediatric urolithiasis, emphasizing environmental and maternal health influences.
- Suggests potential targets for intervention, including parental lifestyle modification and improved maternal healthcare.
- Underscores the importance of considering genetic predispositions alongside environmental triggers.
Abstract:
Risk factors of metabolic disturbances in children with urolithiasis were studied in 38 children aged 1.7 to 14 years. The information for the disease history was obtained from the parents of the children participating in the study. The parents filled in special questionnaire which has detected that 14.2% of fathers and 72% of mothers had chronic diseases; when pregnant, 81.5% mothers had toxicosis and gestosis, 23% suffered from various viral and bacterial infections treated for a short time with drugs; 63% mothers did not keep diet before pregnancy but pregnancy and lactation made 77% of them pay due attention to their food and diet regime. Breast feeding lasted for the first 2-6 and 1-2 months in 38 and 50% mothers, respectively. Feeding was mixed from birth in 23% babies. Development of metabolic disturbances in children leading to urolithiasis depends on many factors closely linked with environment pollutants, life style of the parents, gynecological health of mothers, intercurrent diseases. Immunogenetic, hereditary mechanisms are involved in triggering urolithiasis in children.
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