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Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
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CD19+CD5+ B cells in primary IgA nephropathy.

He Yuling1, Xiao Ruijing, Ji Xiang

  • 1Department of Immunology, Wuhan University School of Medicine, Wuhan University, Dong Hu Road 115, 430071 Wuchang, Wuhan, P.R. China.

Journal of the American Society of Nephrology : JASN
|July 25, 2008
PubMed
Summary
This summary is machine-generated.

CD19(+)CD5(+) B cells are key players in IgA nephropathy, a kidney disease. These cells are more frequent in patients and decrease with effective treatment, suggesting their role in disease development.

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Area of Science:

  • Immunology
  • Nephrology
  • Cell Biology

Background:

  • Primary IgA nephropathy pathogenesis remains unclear, particularly the source and deposition of IgA.
  • CD19(+)CD5(+) B cells are known IgA producers and implicated in autoimmune diseases.

Purpose of the Study:

  • To investigate the role of CD19(+)CD5(+) B cells in primary IgA nephropathy.
  • To assess the frequency, characteristics, and behavior of these B cells in IgA nephropathy patients.

Main Methods:

  • Flow cytometry, quantitative PCR, and confocal microscopy were employed.
  • Analysis included peripheral blood, peritoneal fluid, and kidney biopsies from 36 IgA nephropathy patients and controls.
  • Compared CD19(+)CD5(+) B cells in patients versus controls and systemic lupus erythematosus patients.

Main Results:

  • CD19(+)CD5(+) B cells were significantly more prevalent in IgA nephropathy patients' blood, fluid, and kidneys compared to controls.
  • Effective treatment of IgA nephropathy led to a significant reduction in these B cells.
  • Cells from untreated patients showed higher IgA levels, increased IFN-gamma production, and greater resistance to apoptosis, which normalized with treatment.

Conclusions:

  • CD19(+)CD5(+) B cells are strongly implicated in the pathogenesis of primary IgA nephropathy.
  • Their frequency and functional properties correlate with disease activity and treatment response.