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Related Experiment Video

Updated: Jul 3, 2026

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Lipostructure technique in Romberg syndrome.

Monica Grimaldi1, Pietro Gentile, Lara Labardi

  • 1Department of Plastic and Reconstructive Surgery, Policlinico Casilino University Tor Vergata, Rome, Italy.

The Journal of Craniofacial Surgery
|July 25, 2008
PubMed
Summary

Parry-Romberg syndrome, or progressive hemifacial atrophy, causes facial tissue loss. A novel sequential treatment combining polylactic acid and the Coleman technique effectively reconstructs facial contours and improves tissue density.

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Area of Science:

  • Plastic Surgery
  • Dermatology
  • Neurology

Background:

  • Progressive hemifacial atrophy, or Parry-Romberg syndrome, is a rare condition causing unilateral facial tissue degeneration.
  • The etiology and pathogenesis of Parry-Romberg syndrome remain unclear, with theories involving the sympathetic nervous system or central nervous system alterations.
  • Common complications include trigeminal neuritis, facial asymmetry, and epilepsy.

Observation:

  • The study presents a clinical case of progressive hemifacial atrophy.
  • The disease progression is typically slow over several years, eventually stabilizing.
  • Current treatments include autogenous fat grafting after disease stabilization.

Findings:

  • A novel two-stage therapeutic approach was proposed: polylactic acid for skin thickening followed by the Coleman technique for facial contour reconstruction.

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  • This sequential treatment aimed to restore superficial facial tissue density and three-dimensional projection.
  • The combined treatment demonstrated efficacy in addressing facial atrophy.

    • Implications:

    • This combined therapeutic strategy offers a promising option for managing progressive hemifacial atrophy.
    • Patient satisfaction suggests the treatment effectively restores facial aesthetics and function.
    • Further research may validate this approach for broader clinical application in treating facial asymmetry.