Related Experiment Video
Updated: Jul 3, 2026

06:51
Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage
Published on: May 6, 2020
On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures
Kyohei Terao1, Masao Washizu, Hidehiro Oana
1Department of Micro Engineering, Kyoto University, Kyoto, 606-8501, Japan. k.terao@kt5.ecs.kyoto-u.ac.jp
Lab on a Chip
|July 25, 2008
Abstract:
We report a novel method for manipulation of single giant DNA molecules under a video microscope. Using optically driven microstructures, we manipulated chromosomal DNA of length in the order of millimetres, extended by electroosmotic flow without DNA breakage in aqueous solution: we picked up DNA, using microfabricated hooks and wound it around microfabricated bobbins.

