Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Allergic Reactions

Allergic Reactions

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Unilateral diseases of the maxillary sinus].

HNO·2020

Same author

Cetuximab, fluorouracil and cisplatin with or without docetaxel for patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (CeFCiD): an open-label phase II randomised trial (AIO/IAG-KHT trial 1108).

European journal of cancer (Oxford, England : 1990)·2019

Same author

[Tonsil surgery in Brandenburg-trends between 2013 and 2017].

HNO·2019

Same author

[Histology of adenoids].

HNO·2018

Same author

[Clinical management of epistaxis].

HNO·2018

Same author

Cats with diabetes mellitus have diastolic dysfunction in the absence of structural heart disease.

Veterinary journal (London, England : 1997)·2017

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

[Ultrastructural changes in allergic rhinitis vs. idiopathic rhinitis].

S Knipping¹, H J Holzhausen, A Riederer

¹Universitätsklinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Kopf - und Halschirurgie, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Strasse 12, 06097 Halle/Saale. stephan.knipping@medizin.uni-halle.de

|July 25, 2008

Summary

Allergic rhinitis (AR) and idiopathic rhinitis (IR) share ultrastructural similarities in nasal mucosa, including neurogenic inflammation. However, IR showed fewer eosinophils and less nitric oxide compared to AR.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Related Experiment Videos

Last Updated: Jul 3, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Area of Science:

Immunohistochemistry
Electron Microscopy
Pathomorphology

Context:

Nasal hyperreactivity is a key factor in allergic rhinitis (AR) and idiopathic rhinitis (IR).
Understanding the pathomorphological differences and similarities in nasal mucosa between AR and IR is crucial for effective treatment strategies.

Purpose:

To investigate and compare the ultrastructural pathomorphological changes in the nasal mucosa of patients with AR and IR.
To identify specific markers, such as substance P (SP), calcitonin-gene-related peptide (CGRP), and endothelial nitric oxide synthase (NOS III), associated with neurogenic inflammation in these conditions.

Summary:

The study utilized immunocytochemical staining and electron microscopy on nasal tissue samples from AR and IR patients.
Both AR and IR exhibited similar ultrastructural features, including significant neurogenic inflammation indicated by SP and CGRP.
Distinct differences were observed, with AR showing extensive edema and cellular infiltration, while IR presented with reduced eosinophils and nitric oxide levels.

Impact:

The findings highlight shared and distinct pathomorphological characteristics of AR and IR at the ultrastructural level.
This research supports the recommendation of anti-inflammatory therapies for both allergic and idiopathic rhinitis, potentially leading to improved patient outcomes.