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Updated: Jul 3, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
IL-6 as a regulatory factor of the humoral response during pregnancy
Valeria Dubinsky1, Gisela Junovich, Teresa Gentile
1Immunology, IDEHU, CONICET/UBA, Buenos Aires, Argentina.
Problem:
Regulatory factors seem to be essential to achieve transition from implantation window to placental vascularization. A novel function of interleukin (IL)-6 in the promotion of Th2 differentiation and inhibition of Th1 polarization has been demonstrated. Considering that Th2 response promotes antibody synthesis, we postulate that IL-6 could be modulating the quality of this response during pregnancy by increasing the proportion of blocking asymmetric antibodies.
Method Of Study:
We investigated expression of blocking-asymmetric-IgG during pregnancy of CBA/J x DBA/2 abortion model treated with IL-6, with regards to CBA/J x BALB/c. We also determined asymmetric-IgG production in IL-6-deficient pregnant mice.
Results:
We found that IL-6 treatment increased asymmetric-IgG in multiparous placentas from abortion combination whereas diminished abortion rate. Moreover, asymmetric-IgG proportion was diminished in sera from IL-6-deficient pregnant mice.
Conclusion:
Modulation of asymmetric antibody synthesis could be another mechanism implicated in the beneficial effect of IL-6 in prevention of murine recurrent abortion.
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