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Related Experiment Video

Updated: Jul 3, 2026

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Recapturing and trapping single molecules with a solid-state nanopore.

Marc Gershow, J A Golovchenko

    Nature Nanotechnology
    |July 26, 2008
    PubMed
    Summary
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    Researchers revealed how double-stranded DNA enters solid-state nanopores. Electric forces guide DNA to the pore, enabling immediate entry and precise macromolecule manipulation for advanced biological studies.

    Area of Science:

    • Nanotechnology
    • Biophysics
    • Molecular Biology

    Background:

    • Solid-state nanopores, mimicking biological channels, offer powerful tools for single macromolecule analysis.
    • Precise control over macromolecule-nanopore interactions is crucial for applications like DNA sequencing and protein folding studies.
    • The mechanism of double-stranded DNA (dsDNA) capture by solid-state nanopores remains poorly understood.

    Discussion:

    • This study investigates dsDNA entry into solid-state nanopores by recapturing molecules post-translocation.
    • Observed recapture rates and times align with predictions from a drift-diffusion model.
    • Electric forces are identified as the primary drivers for DNA capture at micrometer distances.

    Key Insights:

    • dsDNA enters solid-state nanopores immediately upon arrival, driven by electric forces.

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    Monitoring Protein Adsorption with Solid-state Nanopores
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    Published on: December 2, 2011

    Related Experiment Videos

    Last Updated: Jul 3, 2026

    Optical Trapping of Nanoparticles
    13:39

    Optical Trapping of Nanoparticles

    Published on: January 15, 2013

    Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
    09:43

    Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

    Published on: October 31, 2013

    Monitoring Protein Adsorption with Solid-state Nanopores
    08:51

    Monitoring Protein Adsorption with Solid-state Nanopores

    Published on: December 2, 2011

  • Recapturing translocated molecules allows for repeated measurements and enhanced accuracy.
  • The findings provide a mechanistic understanding of DNA-nanopore interactions.

    • Outlook:

    • This work enables probing macromolecule dynamics at sub-millisecond timescales and sub-micrometer resolutions.
    • Demonstrates potential for trapping, studying, and manipulating individual macromolecules in solution.
    • Advances the development of nanopore-based technologies for biological research and diagnostics.