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[Decrease of the postoperative inflammatory reaction during pars plana vitrectomy (PPV) after administration of
Anna Mańkowska1, Robert Rejdak, Agnieszka Oleszczuk
1Katedra i Klinika Okulistyki Akademii Medycznej w Lublinie.
Purpose:
To prospectively evaluate the effect on postoperative inflammatory reaction and recovery after application of triamcinolone acetonide (TA) during pars plana vitrectomy (PPV), to visualize the vitreous.
Material And Methods:
Pars plana vitrectomy (PPV) was performed in 45 patients (21 males, 24 females) (29 with retinal detachment, 6 with macular hole, 1 with cystoid macular edema, 3 with diabetic retinopathy, 3 with vitreous haemorrhage, 1 with preretinal membrane, 1 with PVR and 1 with lens luxation). After surgical separation of the posterior vitreous and removal of any visible epiretinal membrane, TA was injected over the posterior pole. For the control group we used 15 patients (10 with retinal detachment, 2 with macular hole, 1 with preretinal membrane, 1 with lens luxation and 1 with vitreous haemorrhage) (10 males, 5 females) treated with PPV but without TA administration. To evaluate the degree of postoperative inflammation and to monitor the dynamics of the blood-aqueous barrier disruption, the laser flare cell meter (Kowa FM-500) was used.
Results:
Tyndalometric mean values in the control group of eyes recorded 1 day after PPV were 32.41 +/- 6.1 ph/ msec while values in TA-treated group were significantly lower (20.26 +/- 2.4, p < 0.02). 10 days after surgery in TA group results were still significantly lower as compared to the control group (16.4 +/- 2.6 vs 32.5 +/- 9.6, p < 0.005). As observed 6 weeks after PPV, tyndalometric recordings in TA-treated group remained lower as those observed in the control group (16.1 +/- 3.1 vs 32.0 +/- 8.1, p < 0.01).
Conclusions:
The eyes which received TA-assisted PPV showed significantly less breakdown of the blood-ocular barrier than those with routine PPV. Intraoperative administration TA facilitates postoperative recovery after surgery lowering the inflammatory reaction.
Insights
Triamcinolone acetonide (TA) injection during pars plana vitrectomy (PPV) significantly reduces postoperative inflammation and improves recovery. TA-assisted PPV demonstrates a lower breakdown of the blood-ocular barrier compared to standard PPV.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Inflammation Research
Context:
- Pars plana vitrectomy (PPV) is a common surgical procedure for various vitreoretinal diseases.
- Postoperative inflammation and blood-ocular barrier disruption can impact patient recovery.
- Triamcinolone acetonide (TA) is a corticosteroid with anti-inflammatory properties.
Purpose:
- To prospectively evaluate the impact of intraoperative triamcinolone acetonide (TA) administration during pars plana vitrectomy (PPV).
- To assess the effect of TA on postoperative inflammatory reactions and recovery.
- To monitor the dynamics of blood-aqueous barrier disruption using laser flare photometry.
Summary:
- Pars plana vitrectomy (PPV) was performed on 45 patients with TA injection and 15 patients without (control group).
- Laser flare cell meter measurements indicated significantly lower tyndalometric values in the TA-treated group at 1 day, 10 days, and 6 weeks post-surgery.
- The TA-assisted PPV group exhibited a significantly reduced breakdown of the blood-ocular barrier compared to the control group.
Impact:
- Intraoperative TA administration effectively lowers postoperative inflammatory responses following PPV.
- TA-assisted PPV facilitates improved and faster postoperative recovery.
- This study highlights a potential adjunctive treatment to enhance outcomes in vitreoretinal surgery.
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