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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Aseptic meningitis and viral myelitis
1Department of Neurology, Holtom-Garrett Program in Neuroimmunology, University of Michigan Medical School, BSRB Room 4007, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. davidira@med.umich.edu
Abstract:
Meningitis and myelitis represent common and very infrequent viral infections of the central nervous system, respectively. The number of cases of viral meningitis that occurs annually exceeds the total number of meningitis cases caused by all other etiologies combined. Focal central nervous system infections, such as occur in the spinal cord with viral myelitis, are much less common and may be confused with noninfectious disorders that cause acute flaccid paralysis. This article reviews some of the important clinical features, epidemiology, diagnostic approaches, and management strategies for patients with aseptic meningitis and viral myelitis. Particular focus is placed on the diseases caused by enteroviruses, which as a group account for most aseptic meningitis cases and many focal infections of the spinal cord.
Insights
Viral meningitis is common, while viral myelitis is rare. This review covers clinical features, epidemiology, diagnosis, and management of aseptic meningitis and viral myelitis, focusing on enteroviruses.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Meningitis and myelitis are viral infections of the central nervous system.
- Viral meningitis is significantly more common than other causes of meningitis.
- Viral myelitis is rare, can be mistaken for noninfectious causes of acute flaccid paralysis.
Purpose of the Study:
- To review clinical features, epidemiology, diagnostics, and management of aseptic meningitis and viral myelitis.
- To highlight the role of enteroviruses in these central nervous system infections.
Main Methods:
- Literature review of viral meningitis and myelitis.
- Focus on enterovirus infections of the central nervous system.
Main Results:
- Enteroviruses are the primary cause of aseptic meningitis.
- Enteroviruses also account for many cases of viral myelitis, a focal spinal cord infection.
Conclusions:
- Understanding the distinct epidemiology and clinical presentations of viral meningitis and myelitis is crucial for accurate diagnosis and treatment.
- Enteroviruses are a key focus for managing these neurological viral infections.
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