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Updated: Jul 3, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
Published on: September 8, 2017
Durable complete response to frontline docetaxel in an advanced prostate cancer patient with favourable CYP1B1
Giovanni Brandi1, Francesco de Rosa, Romano Danesi
1Institute of Haematology and Medical Oncology L. e A. Seràgnoli, Policlinico Sant'Orsola Malpighi, University of Bologna, Via Massarenti 9, Bologna, Italy. giovanni.brandi@unibo.it
Abstract:
Docetaxel is currently indicated for androgen-independent, metastatic prostate cancer; there is also evidence demonstrating the role of CYP1B1 in modulating the activity of the drug. We present the case of a man with residual disease after radical prostatectomy treated successfully with docetaxel chemotherapy. After only two cycles of therapy, a complete remission was obtained and then consolidated with additional cycles of docetaxel and radiotherapy. Prospective genetic analysis had shown that the patient had a favourable CYP1B1 genotype. He has been disease free since August 2006. Prospective trials investigating this strategy are warranted.
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