Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scaling concepts in cellular and subcellular dynamics.

G T Matioli1

  • 1USC School of Medicine, Los Angeles 90033.

Medical Hypotheses
|April 1, 1991
PubMed
Summary

Hemopoietic stem cells (SCs) exhibit recursive processes at subcellular levels. These can amplify genomic changes, leading to chaotic oscillations and predictable, yet seemingly random, cell disorders like leukemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homotopic dynamics of telomeric loops in mammalian chromatids.

Journal of theoretical biology·2007
Same author

Chromatid transport by pantographic motors (PMS).

Medical hypotheses·2003
Same author

Euchromatinization of mammalian nuclei.

Medical hypotheses·2002
Same author

BCR-ABL insufficiency for the transformation of human stem cells into CML.

Medical hypotheses·2002
Same author

A note on the meaning of stochasticity.

Medical hypotheses·2002
Same author

On metastatic seeding of regional lymph nodes.

Medical hypotheses·2002

Area of Science:

  • Cell Biology
  • Genomics
  • Chaos Theory

Background:

  • Hemopoietic stem cells (SCs) play a crucial role in blood formation.
  • Understanding SC behavior at subcellular levels is key to deciphering cellular disorders.
  • Existing models may not fully capture the complexity of SC dynamics.

Purpose of the Study:

  • To map states typical of hemopoietic stem cells.
  • To identify parameters governing SC behavior down to subcellular structures.
  • To explain malignant growth paradoxes using principles of chaos theory.

Main Methods:

  • Developing state maps for hemopoietic stem cells.
  • Analyzing parameters like fractal dimensions and oscillatory behavior.
  • Investigating subcellular structures including interphase genome and chromatin dynamics.

Main Results:

  • Recursive processes were observed at subcellular scales (genome, chromatin, DNA motion).
  • These iterations can amplify genomic singularities, causing qualitative and quantitative cell changes.
  • Hemopoietic cells, when interpreted as chaotic oscillators, show sensitivity to initial conditions.

Conclusions:

  • Subtle initial conditions in hemopoietic stem cells can lead to statistically deterministic outcomes.
  • The chaotic oscillator model explains certain paradoxes in malignant growth, such as leukemia.
  • This framework offers predictable insights into cell disorders within specific time limits.

Related Experiment Videos