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Related Experiment Videos

Phosphate kinetics in dialysis patients.

T Haas1, D Hillion, G Dongradi

  • 1CMCO Evry, Evry Clinic, Dialysis Department, France.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1991
PubMed
Summary

Plasma phosphate levels exhibit unique kinetics during hemodialysis, with a dip and rebound pattern linked to cellular shifts. Potassium levels significantly influence these phosphate fluxes, suggesting a strong interrelationship.

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Area of Science:

  • Nephrology
  • Biochemistry
  • Physiology

Background:

  • Plasma phosphate concentrations demonstrate specific kinetics during extrarenal therapy.
  • These kinetics involve a steady-state nadir followed by a rebound within hours post-session.
  • High ultrafiltration rates in hemodialysis are associated with these observed phosphate patterns.

Purpose of the Study:

  • To investigate the kinetics of plasma phosphate concentrations during hemodialysis.
  • To explore the relationship between phosphate and potassium fluxes.
  • To understand the influence of cellular to extracellular phosphate transfer.

Main Methods:

  • Analysis of plasma phosphate concentrations during hemodialysis sessions with varying ultrafiltration rates.
  • Investigation of phosphate kinetics with different acetate or bicarbonate reinjection fluids.

Related Experiment Videos

  • Utilizing 31P-NMR studies and varying potassium concentrations in reinjection fluid to assess cellular phosphate and potassium fluxes.

    • Main Results:

    • Phosphate kinetics are observed during hemodialysis with high ultrafiltration rates, characterized by a nadir and subsequent rebound.
    • Phosphate transfer from cellular to extracellular space, not delayed mass transfer, explains these kinetics.
    • A significant linear relationship was established between cellular potassium and phosphate fluxes, indicating potassium's influence.

    Conclusions:

    • Phosphate kinetics during hemodialysis are primarily driven by cellular shifts and influenced by potassium fluxes.
    • Potassium removal during hemodialysis significantly impacts phosphate transfer.
    • Modifications in phosphate levels during hemodialysis sessions did not show significant differences in patient concentrations two days later.