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Related Concept Videos

Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Longevity genomics across species.

Matt Kaeberlein1

  • 1Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Current Genomics
|July 29, 2008
PubMed
Summary
This summary is machine-generated.

Genome-wide studies identified over 100 longevity genes in yeast and worms, revealing conserved aging pathways. Future research aims to link these findings to human aging and develop therapies for age-related diseases.

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Last Updated: Jul 3, 2026

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08:53

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine

Published on: January 26, 2024

Area of Science:

  • Genetics and Molecular Biology
  • Aging Research
  • Comparative Genomics

Background:

  • Genome-wide studies in model organisms like yeast (Saccharomyces cerevisiae) and worms (Caenorhabditis elegans) have identified numerous genes influencing lifespan.
  • These studies have begun to elucidate conserved pathways connecting nutrient availability and growth signals to the aging process.

Purpose of the Study:

  • To summarize findings from unbiased genome-wide studies on longevity in S. cerevisiae and C. elegans.
  • To highlight the identification of genes and pathways involved in aging.
  • To discuss the implications for understanding conserved aging mechanisms and future therapeutic development for human age-associated diseases.

Main Methods:

  • Unbiased genome-wide screening approaches in S. cerevisiae and C. elegans.
  • Comparative analysis of identified longevity genes across species.
  • Investigation of conserved pathways linking nutrient/growth factor signaling to lifespan.

Main Results:

  • Identification of over one hundred genes that determine lifespan in one or both model organisms.
  • Uncovering of key conserved pathways that link nutrient and growth factor cues to longevity.
  • Establishment of quantitative measures for assessing the evolutionary conservation of aging.

Conclusions:

  • Longevity genes and pathways are significantly conserved between yeast and worms.
  • A substantial genetic basis for aging has been uncovered in these model systems.
  • A critical future challenge is to translate these findings to human aging and develop targeted therapies for age-related diseases.