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Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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[The effects of ADAM28 on HDPC biological characteristics]

Zheng Zhao1, Jun-Ming Xu, Wei-Li Zhao

  • 1Department of Stomatology, The 401st Hospital of Jinan Military Area, PLA. Qingdao 266071, China. zhaozheng170@sohu.com

Shanghai Kou Qiang Yi Xue = Shanghai Journal of Stomatology
|July 29, 2008
PubMed
Abstract

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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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The writer is an enzyme that can...
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Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Heterochromatin

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Position-effect Variegation

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Euchromatin

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