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Updated: Jul 3, 2026

DNA Vector-based RNA Interference to Study Gene Function in Cancer
Published on: June 4, 2012
Tissue-specific shRNA delivery: a novel approach for gene therapy in cancer
Shilenath Ghatak1, Viacent C Hascall, Franklin G Berger
1Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina 29425, USA. ghatak@musc.edu
Abstract:
A novel tissue-specific shRNA delivery system has been developed using cre-lox technology. Conditionally silenced pSico vector containing oligonucleotides of CD44shRNA and tissue-specific promoter-driven Cre-recombinase expression vector are packaged into transferrin-coated nanoparticles that can deliver shRNA into specific tumors. This system has strong potential in cancer therapy.
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