Related Experiment Video
Updated: Jul 3, 2026
06:31
Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
Published on: October 6, 2023
Altered bone remodeling in psoriatic arthritis
Kofi A Mensah1, Edward M Schwarz, Christopher T Ritchlin
1Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA. edward_schwarz@urmc.rochester.edu
Current Rheumatology Reports
|July 30, 2008
Summary
Osteoimmunology reveals how immune cells impact bone health in psoriatic arthritis (PsA). Understanding these interactions guides new treatments for bone remodeling in this inflammatory condition.
Area of Science:
- Bone biology
- Immunology
- Osteoimmunology
Background:
- Bone is a dynamic tissue constantly interacting with various cells.
- Emerging research highlights significant connections between the immune and skeletal systems.
- This has led to the establishment of osteoimmunology, a field bridging bone biology and immunology.
Purpose of the Study:
- To review the disruption of bone homeostasis in psoriatic arthritis (PsA).
- To discuss the roles of osteoclasts, osteoblasts, and signaling pathways in altered bone remodeling in PsA.
- To examine the impact of tumor necrosis factor inhibition on bone metabolism in PsA.
Main Methods:
- Literature review of recent studies in osteoimmunology and psoriatic arthritis.
- Analysis of cellular and molecular mechanisms underlying bone remodeling in PsA.
- Examination of therapeutic effects of TNF inhibition on bone in PsA.
Main Results:
- PsA involves significant disruption of normal bone homeostasis.
- Osteoclasts, osteoblasts, and specific signaling pathways are key players in altered bone remodeling.
- Tumor necrosis factor inhibition shows effects on both bone resorption and new bone formation in PsA.
Conclusions:
- Osteoimmunology provides a framework for understanding and treating bone pathologies in PsA.
- Targeting immune-mediated pathways offers potential therapeutic strategies for PsA-related bone issues.
- Further research in osteoimmunology can translate basic science discoveries into clinical applications for inflammatory joint diseases.
Related Concept Videos
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...