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Updated: Jul 3, 2026
12:37
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Broad spectrum bioactive sunscreens
Maria Valéria Robles Velasco1, Fernanda Daud Sarruf, Idalina Maria Nunes Salgado-Santos
1Laboratory of Cosmetology, Department of Pharmacy, School of Pharmaceutical Sciences of University of São Paulo, São Paulo, SP, Brazil.
International Journal of Pharmaceutics
|July 30, 2008
Summary
This study developed effective broad-spectrum sunscreens using natural extracts like Passiflora incarnata L. and Plantago lanceolata, combined with UV filters. The best formulation achieved an estimated sun protection factor (SPF) of 20.07, enhancing UVA protection.
Area of Science:
- Cosmetic Science
- Photoprotection
- Natural Product Chemistry
Background:
- Sunscreens with reduced chemical UV filters and enhanced UV absorption are of interest.
- Polyphenolic compounds show potential photoprotection due to structural similarities with organic UV filters.
Purpose of the Study:
- To develop bioactive sunscreen delivery systems using rutin, Passiflora incarnata L., and Plantago lanceolata extracts.
- To evaluate the photoprotection efficacy of these systems, alone or combined with UV filters.
Main Methods:
- UV transmission was measured using diffuse transmittance and an integrating sphere.
- In vitro photoprotection was assessed by estimated sun protection factor (SPF), Boot's Star Rating, UVA/UVB ratio, and critical wavelength (λc).
Main Results:
- SPF values ranged from 0.97 to 28.06.
- A formulation with 1.68% P. incarnata L. extract, 7.0% ethylhexyl methoxycinnamate, 2.0% benzophenone-3, and 2.0% TiO(2) achieved an SPF of 20.07.
- This formulation improved UVA protection (UVA/UVB ratio 0.52, λc 368.6nm).
Conclusions:
- Bioactive compounds and UV filters interact, influencing photoprotection efficacy.
- Natural extracts can enhance sunscreen formulations, offering broad-spectrum protection.
- The developed sunscreen delivery system demonstrates significant potential for improved sun protection.
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