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Updated: Jun 26, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
A New TRADDition in intracellular antiviral signaling
Eric M Pietras1, Genhong Cheng
1Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Abstract:
To effectively defeat viral infection, a mammalian host must detect the presence of viruses and activate a robust antiviral response, which is mediated by cytokines known as type I interferons (IFNs). Much excitement has been generated by the discovery of the retinoic acid-induced gene 1-like helicase (RLH) pathway, which detects RNA-containing viruses in the cytoplasm and activates the type I IFN response. A study now describes a role for the tumor necrosis factor receptor (TNFR)-associated death domain (TRADD) in the antiviral response and sheds new light on how the RLH signaling complex is organized upon viral infection.
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