Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Yellow mealworm: effects of adults breeding density on adults and larvae performances from an industrial perspective.

Animal : an international journal of animal bioscience·2024

Same author

Right putamen and age are the most discriminant features to diagnose Parkinson's disease by using <sup>123</sup>I-FP-CIT brain SPET data by using an artificial neural network classifier, a classification tree (ClT).

Hellenic journal of nuclear medicine·2018

Same author

Brain natriuretic peptide as a cardiac marker of transient radiotherapy-related damage in left-sided breast cancer patients: A prospective study.

Breast (Edinburgh, Scotland)·2015

Same author

Periodontal healing after 'orthodontic extraction' of mandibular third molars: a retrospective cohort study.

International journal of oral and maxillofacial surgery·2014

Same author

The Vienna protocol and perspectives in radionuclide therapy.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2011

Same author

SPECT/CT with a hybrid imaging system in the study of lower gastrointestinal bleeding with technetium-99m red blood cells.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2008

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

Relationship between PET-FDG and MRI apparent diffusion coefficients in brain tumors.

B Palumbo¹, F Angotti, G D Marano

¹Nuclear Medicine Section, Department of Surgical, Radiological and Odontostomatological Sciences, University of Perugia, Perugia, Italy. mednuc@unipg.it

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR), [And] Section of the Society Of

|July 31, 2008

Summary

This study found an inverse relationship between 2-deoxy-2[(18)F]fluoro-D-glucose ([(18)F]FDG) positron emission tomography (PET) and apparent diffusion coefficients (ADC) in brain tumors. Higher [(18)F]FDG uptake correlated with lower ADC values, suggesting increased cellularity.

More Related Videos

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Related Experiment Videos

Last Updated: Jul 3, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Area of Science:

Neuroimaging
Oncology
Radiology

Background:

Brain tumors exhibit complex cellularity and metabolic activity.
Positron emission tomography (PET) with 2-deoxy-2[(18)F]fluoro-D-glucose ([(18)F]FDG) measures metabolic activity.
Diffusion-weighted magnetic resonance imaging (DWI) with apparent diffusion coefficients (ADC) assesses tissue microstructure.

Purpose of the Study:

To investigate the relationship between [(18)F]FDG PET and ADC values in brain tumors.
To determine if metabolic activity correlates with water diffusion characteristics in brain lesions.

Main Methods:

Fifteen patients with 18 metastatic brain lesions were included.
Evaluated using gadolinium-enhanced fast spoiled gradient echo (Gd-FSPGR), DWI with ADC maps, and [(18)F]FDG PET.
Regions of interest (ROIs) were analyzed, and linear regression was performed on PET and ADC ratios.

Main Results:

An inverse correlation was observed between [(18)F]FDG PET and ADC ratios (r(2)=0.2746, P=0.0256).
High PET ratios corresponded to low ADC ratios, and vice versa.
This suggests that areas with high metabolic activity have restricted water diffusion.

Conclusions:

Preliminary data indicate an inverse relationship between [(18)F]FDG PET uptake and ADC values in brain tumors.
Higher cellularity may lead to increased impedance of water diffusion (low ADC) and higher [(18)F]FDG uptake.
Conversely, lower cellularity is associated with increased ADC and decreased [(18)F]FDG uptake.