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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Published on: January 7, 2014

Glioblastoma and stem cells.

C Altaner1

  • 1Cancer Research Institute SAS Bratislava, Slovakia. exonalt@savba.sk

Neoplasma
|July 31, 2008
PubMed
Summary

Glioblastoma contains cancer stem cells responsible for tumor recurrence and resistance to therapy. Bone morphogenetic protein 4 (BMP4) shows potential in targeting these cells for novel glioblastoma treatments.

Area of Science:

  • Neuro-oncology
  • Cancer Stem Cell Biology
  • Molecular Therapy

Background:

  • Glioblastoma is a heterogeneous tumor comprising tumor cells and cancer stem cells (CSCs).
  • Glioma CSCs exhibit stem cell characteristics, including self-renewal and expression of CD133.
  • These CSCs possess high tumorigenic potential and are implicated in tumor progression and therapeutic resistance.

Purpose of the Study:

  • To review evidence on glioblastoma heterogeneity and the role of CSCs.
  • To explore CSC-mediated chemoresistance and radioresistance mechanisms.
  • To discuss potential CSC-targeting therapies, including stem cell-based approaches and BMP4.

Main Methods:

  • Review of existing literature on glioblastoma, cancer stem cells, and therapeutic strategies.

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Published on: January 7, 2014

Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion
09:36

Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

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  • Analysis of CSC characteristics, including gene expression (CD133) and self-renewal.
  • Evaluation of CSC contributions to therapeutic resistance via DNA repair mechanisms.

    • Main Results:

    • Glioblastoma CSCs recapitulate tumor heterogeneity and drive recurrence due to chemo- and radioresistance.
    • CSCs enhance radioresistance by increasing DNA repair capacity via checkpoint activation.
    • Mesenchymal and neural stem cells show potential for targeted drug delivery to brain tumors.
    • Bone morphogenetic protein 4 (BMP4) effectively inhibits proliferation of CD133+ cells in vitro and tumor growth in vivo.

    Conclusions:

    • Cancer stem cells are critical drivers of glioblastoma progression and recurrence.
    • Targeting CSCs, potentially with agents like BMP4, offers a promising therapeutic strategy.
    • Stem cell-based therapies, including gene therapy and targeted delivery systems, represent a novel approach for glioblastoma treatment.