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High prevalence of Cag-A positive H. pylori strains in ischemic stroke: a primary care multicenter study

Rudy De Bastiani1, Maurizio Gabrielli, Enzo Ubaldi

  • 1GIGA-CP (Italian Group for Primary Care Gastroenterology), Feltre (BL) Italy.

Helicobacter
|July 31, 2008
PubMed

Insights

Helicobacter pylori infection, specifically CagA-positive strains, is significantly linked to a higher risk of atherosclerotic stroke in primary care patients. This association highlights a potential factor in stroke development.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Cardiovascular Medicine

Background:

  • Previous research indicated a link between CagA-positive H. pylori and ischemic stroke.
  • This study investigated H. pylori infection and CagA status in atherosclerotic stroke patients within a primary care setting.

Purpose of the Study:

  • To determine the prevalence of H. pylori infection.
  • To assess the association between CagA-positive H. pylori strains and atherosclerotic stroke.

Main Methods:

  • 106 atherosclerotic stroke patients and 106 matched controls were enrolled.
  • H. pylori infection was diagnosed using the [13]C-urea breath test.
  • CagA-specific IgG antibodies were measured in infected individuals.

Main Results:

  • A trend for higher H. pylori prevalence was seen in stroke cases (63%) versus controls (54%).
  • CagA positivity demonstrated a significant association with increased atherosclerotic stroke risk (aOR 2.69).

Conclusions:

  • CagA-positive H. pylori strains are significantly associated with atherosclerotic stroke.
  • This study is unique as it was conducted in primary care and focused on active infections.
Abstract

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