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Thyroid abnormalities in pediatric patients with vitiligo in New York City

Odelya E Pagovich1, Jonathan I Silverberg, Elie Freilich

  • 1Sackler University, Tel Aviv, Israel.

Cutis
|August 1, 2008
PubMed

Insights

Pediatric vitiligo patients, especially those with nonsegmental vitiligo vulgaris, show a significant rate of active thyroid disease. Early thyroid screening is recommended for these children to detect potential autoimmune thyroid conditions.

Area of Science:

  • Dermatology
  • Endocrinology
  • Pediatrics

Background:

  • The association between vitiligo and thyroid disease is recognized.
  • The specific risk factors for thyroid disease and its prevalence in childhood vitiligo remain unclear.
  • Vitiligo vulgaris is the most common type of vitiligo.

Purpose of the Study:

  • To investigate the prevalence of thyroid disease in pediatric patients diagnosed with vitiligo vulgaris.
  • To determine if the type of vitiligo (segmental vs. nonsegmental) influences the risk of thyroid disease in children.

Main Methods:

  • Retrospective chart review of 67 pediatric dermatology patients with vitiligo vulgaris.
  • Analysis of thyroid disease testing results for patients with available data (N=28).
  • Categorization of vitiligo cases into segmental and nonsegmental types.

Main Results:

  • Seven out of 28 pediatric patients (25%) with available thyroid test results had active thyroid disease.
  • None of the patients with active thyroid disease had segmental vitiligo.
  • An overall thyroid disease rate of 10.4% (7/67) was estimated across all reviewed charts.

Conclusions:

  • A substantial proportion of children with vitiligo vulgaris, particularly the nonsegmental type, exhibit active thyroid disease.
  • The findings support the need for routine thyroid screening in pediatric patients diagnosed with generalized nonsegmental vitiligo vulgaris.
  • Results align with European literature, emphasizing the importance of early detection and management of associated thyroid conditions.

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