Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Bacterial translocation.

C E Edmiston¹, R E Condon

¹Surgical Microbiology Research Laboratory, Medical College of Wisconsin, Milwaukee 53226.

Surgery, Gynecology & Obstetrics

|July 11, 1991

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving surgical site infection prevention in Asia-Pacific through appropriate surveillance programs: Challenges and recommendation.

Infection, disease & health·2021

Same author

World Health Organization: global guidelines for the prevention of surgical site infection.

The Journal of hospital infection·2017

Same author

Meta-analysis of the potential economic impact following introduction of absorbable antimicrobial sutures.

The British journal of surgery·2017

Same author

A narrative review of microbial biofilm in postoperative surgical site infections: clinical presentation and treatment.

Journal of wound care·2016

Same author

Approach to chronic wound infections.

The British journal of dermatology·2015

Same author

Questionable safety of pyloromyotomy in district general hospitals.

Journal of the Royal Society of Medicine·2010

Same journal

THE USE OF COMBINED PRESERVATION TECHNIQUES FOR EXTENDED STORAGE OF ORTHOTOPIC LIVER HOMOGRAFTS.

Surgery, gynecology & obstetrics·2010

Same journal

The Role of Electrical Pacemakers in the Treatment of Unexpected Cardiac Arrest.

Surgery, gynecology & obstetrics·2010

Same journal

Colonic and proctoscopic diseases.

Surgery, gynecology & obstetrics·2010

Same journal

A summary of the surgical aspects of certain sulfonamides and antibiotic agents.

Surgery, gynecology & obstetrics·2010

Same journal

Penetrating cranial wounds; a summary of methods used in management; collective review.

Surgery, gynecology & obstetrics·2010

Same journal

The use of compression in the treatment of injuries.

Surgery, gynecology & obstetrics·2010

See all related articles

Bacterial translocation, the movement of microbes across the gut barrier, remains poorly understood. Research suggests maintaining intestinal mucosal integrity is key to preventing infections from gut bacteria.

Area of Science:

Microbiology
Immunology
Gastroenterology

Background:

Bacterial translocation, the movement of viable bacteria across the intestinal barrier, is a recognized phenomenon.
It is implicated in intestinal origin portal sepsis, particularly in critically ill and immunocompromised patients.

Observation:

The precise mechanisms driving microbial transport across the intestinal epithelium are currently unknown.
Proposed mechanisms include active epithelial uptake and phagocyte-mediated transport.
Bacteria move to mesenteric lymph nodes and distant organs.

Findings:

Current clinical understanding relies heavily on animal studies (dogs, rats, mice).
Ongoing research indicates a strong link between intestinal mucosal integrity and infections caused by indigenous gastrointestinal bacteria.

Related Experiment Videos

Implications:

Understanding bacterial translocation is crucial for managing sepsis in vulnerable patient populations.
Further research is needed to elucidate the exact mechanisms and develop targeted therapies.
Maintaining gut barrier function may be a critical therapeutic strategy.