Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Chi-square Analysis02:46

Chi-square Analysis

The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
Study Design in Statistics01:15

Study Design in Statistics

A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights for inclusive upstream engagement with migrant farmworkers in agriculture: A case study from the US-Mexico border.

Ambio·2026
Same author

Examining media coverage of ethical dimensions of advanced algorithmic technology.

Public understanding of science (Bristol, England)·2026
Same author

Strategic planning of prevention and surveillance for emerging diseases and invasive species.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Management Agencies can Leverage Animal Social Structure for Wildlife Disease Surveillance.

Journal of wildlife diseases·2025
Same author

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology.

Nature communications·2025
Same author

A Scalable Empirical Bayes Approach to Variable Selection in Generalized Linear Models.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2024

Related Experiment Videos

Open access publishing, article downloads, and citations: randomised controlled trial.

Philip M Davis1, Bruce V Lewenstein, Daniel H Simon

  • 1Department of Communication, Cornell University, Ithaca, NY 14853, USA. pmd8@cornell.edu

BMJ (Clinical Research Ed.)
|August 2, 2008
PubMed
Summary

Open access publishing increases article downloads and readership significantly. However, this study found no evidence that open access leads to more citations in the first year compared to traditional subscription access.

Related Experiment Videos

Area of Science:

  • Biomedical research
  • Scholarly communication
  • Publishing industry

Background:

  • The proliferation of open access (OA) publishing models aims to increase the accessibility of scientific literature.
  • Understanding the impact of OA on article dissemination and academic influence is crucial for researchers and publishers.

Purpose of the Study:

  • To quantify the effect of free access to scientific articles on their download rates and subsequent citation counts.
  • To compare the readership and citation impact of articles made available through open access versus traditional subscription models.

Main Methods:

  • A randomized controlled trial was conducted involving 1619 research articles and reviews across 11 journals from the American Physiological Society.
  • Articles were randomly assigned to either open access or subscription access upon online publication.
  • Article readership was measured by full-text downloads, PDF downloads, abstract downloads, and unique visitor IP addresses. Citations were tracked for one year post-publication.

Main Results:

  • Open access articles demonstrated substantially higher readership, with an 89% increase in full-text downloads and a 42% increase in PDF downloads within the first six months.
  • Unique visitor numbers were 23% higher for open access articles, while abstract downloads decreased by 24%.
  • Crucially, open access articles were not cited more frequently than subscription access articles within the first year, with logistic and negative binomial regression analyses confirming no citation advantage.

Conclusions:

  • Open access publishing demonstrably enhances article reach and reader engagement compared to subscription access.
  • The study found no evidence of a citation advantage for open access articles in the initial year post-publication.
  • Widely reported citation advantages for open access may stem from confounding factors rather than the access model itself.