Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 3, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Circulating mutant DNA to assess tumor dynamics.

Frank Diehl1, Kerstin Schmidt, Michael A Choti

  • 1The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

Nature Medicine
|August 2, 2008
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive Genomic Analysis of Normal and Cancer Cells Elucidates the Elevated Mutation Burden in Cancer.

Cancer research·2026
Same author

Spatial Regulation of CAR Signaling Enables Logic-Gated Activity.

bioRxiv : the preprint server for biology·2026
Same author

A plasma-based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Lethal toxin-equipped effector cells for the potential treatment of cancer.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A plasma-based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation.

medRxiv : the preprint server for health sciences·2026
Same author

Evidence that extra copies of chromosome 1q play a role in the early phases of pancreatic neoplasia.

Science advances·2026

Researchers developed a sensitive method to measure circulating tumor DNA (ctDNA) in colorectal cancer patients. This technique reliably tracks tumor changes during treatment, offering a personalized approach for cancer management.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circulating nucleic acids have improved management of chronic viral infections like HIV.
  • Tumor-specific DNA (ctDNA) offers potential as a cancer marker.
  • Detecting low ctDNA levels amidst normal DNA is challenging for clinical use.

Purpose of the Study:

  • To apply a highly sensitive approach for quantifying ctDNA.
  • To monitor tumor dynamics in colorectal cancer patients undergoing therapy.

Main Methods:

  • Quantified ctDNA in 162 plasma samples from 18 colorectal cancer patients.
  • Utilized a sensitive detection method for ctDNA fragments.

Main Results:

  • ctDNA measurements reliably monitored tumor dynamics.

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Related Experiment Videos

Last Updated: Jul 3, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

  • Demonstrated feasibility in patients undergoing surgery or chemotherapy.

    • Conclusions:

    • ctDNA quantification is a reliable method for monitoring tumor dynamics.
    • This personalized genetic approach may be applicable to various cancer types.