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Updated: Jul 3, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
Published on: June 29, 2018
Linking cellular mechanisms to behavior: entorhinal persistent spiking and membrane potential oscillations may
Michael E Hasselmo1, Mark P Brandon
1Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Sreet, Boston, MA 02215, USA. hasselmo@bu.edu
Abstract:
The entorhinal cortex plays an important role in spatial memory and episodic memory functions. These functions may result from cellular mechanisms for integration of the afferent input to entorhinal cortex. This article reviews physiological data on persistent spiking and membrane potential oscillations in entorhinal cortex then presents models showing how both these cellular mechanisms could contribute to properties observed during unit recording, including grid cell firing, and how they could underlie behavioural functions including path integration. The interaction of oscillations and persistent firing could contribute to encoding and retrieval of trajectories through space and time as a mechanism relevant to episodic memory.
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