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Related Experiment Videos

Behçet's disease in Portugal.

P de Souza-Ramalho1, M F D'Almeida, J P Freitas

  • 1Department of Ophthalmology, Lisbon University, Hospital de Santa Maria.

Acta Medica Portuguesa
|March 1, 1991
PubMed
Summary

Behçet

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Area of Science:

  • Rheumatology
  • Immunology
  • Ophthalmology

Background:

  • Behçet's disease is a rare multisystemic inflammatory disorder.
  • Historical data on Behçet's disease in Portugal is limited.
  • Previous reports indicated a low prevalence until the late 20th century.

Purpose of the Study:

  • To analyze the epidemiological and clinical characteristics of Behçet's disease in Portugal.
  • To report the incidence and prevalence of the disease across different regions of Portugal.
  • To document treatment modalities and outcomes in Portuguese patients.

Main Methods:

  • Retrospective analysis of 156 diagnosed patients with Behçet's disease in Portugal.
  • Review of patient records from various regions including Lisbon, Oporto, and Coimbra.
  • Inclusion of data on clinical manifestations, HLA-B5 association, and treatment regimens.

Main Results:

  • 156 patients diagnosed over several decades, with a significant increase in diagnoses in recent years.
  • High incidence of oral ulcerations (100%) and ocular involvement (87%) observed.
  • HLA-B5 association found in 50% of patients; mortality rate of at least 4 cases, with 3 due to neuro-Behçet.

Conclusions:

  • Behçet's disease is present in Portugal with characteristic multisystemic involvement.
  • Ocular and oral manifestations are highly prevalent.
  • Standard and advanced therapies were employed, with notable cases of neuro-Behçet and fatalities.

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