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Updated: Jul 3, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Enantioselective synthesis of tetrafluorinated glucose and galactose
Roxana S Timofte1, Bruno Linclau
1University of Southampton, School of Chemistry, Highfield, Southampton SO17 1BJ.
Abstract:
Polyfluorinated carbohydrates have emerged as interesting probes to investigate "polar hydrophobicity" effect(s) in protein-carbohydrate interactions. A convenient enantioselective synthesis of tetrafluorinated analogues of two of the most important monosaccharides, D-glucose and D-galactose, is reported, as well as our first results regarding the glycosylation of these sugar analogues.
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