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Pediatric hepatic hemangiosarcoma in a rhesus macaque (Macaca mulatta)
A F Mejía1, L Gierbolini, B Jacob
1Department of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA.
Journal of Medical Primatology
|August 2, 2008
Summary
A rare hemangiosarcoma in a young rhesus monkey
Area of Science:
- Veterinary Pathology
- Comparative Oncology
Background:
- Pediatric hepatic angiosarcoma is a rare childhood cancer with a poor prognosis.
- Hemangiosarcoma is infrequently observed in non-human primates.
Observation:
- A 3-year-old rhesus monkey presented with hemoabdomen and a large liver mass.
- Gross examination revealed a 4x3x3 cm liver mass with smaller lesions.
- Histopathology confirmed a poorly differentiated hemangiosarcoma.
Findings:
- Immunohistochemistry identified endothelial-specific markers CD31 and von Willebrand factor (vWF).
- The tumor showed a solid growth pattern, distinct from typical Kaposi-form angiosarcoma.
- No metastases were found in other organs.
Implications:
- This case highlights the rarity of hemangiosarcoma in non-human primates.
- The tumor's characteristics suggest a resemblance to pediatric hepatic angiosarcoma in humans.
- This finding contributes to comparative oncology research and understanding of rare tumors.
