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Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Chronic Inflammation: Introduction01:12

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Related Experiment Video

Updated: Jul 3, 2026

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
09:01

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

Published on: December 30, 2014

Inflammation, ageing and cancer.

Sonya Vasto1, Giuseppe Carruba, Domenico Lio

  • 1Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy.

Mechanisms of Ageing and Development
|August 2, 2008
PubMed
Summary

Aging increases cancer risk due to chronic inflammation. Centenarians show genetic resistance to inflammation, suggesting a protective effect against age-related cancers.

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Last Updated: Jul 3, 2026

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
09:01

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

Published on: December 30, 2014

Area of Science:

  • Gerontology
  • Oncology
  • Immunology

Background:

  • Cancer incidence and mortality rise with age, peaking around 90 years.
  • Aging is characterized by low-grade systemic inflammation, linked to age-related diseases.
  • Chronic inflammation and infection are strongly associated with cancer development.

Purpose of the Study:

  • To review inflammatory mediators linking cancer and aging.
  • To explore the role of inflammation in age-related diseases and cancer.
  • To investigate the genetic factors in centenarians related to inflammation control and cancer resistance.

Main Methods:

  • Literature review focusing on inflammation, aging, longevity, and cancer.
  • Analysis of clinical and epidemiological studies on inflammation and cancer.
  • Examination of genetic markers in centenarians associated with inflammation control.

Main Results:

  • A pro-inflammatory status in aging may link cancer to aging.
  • Inflammation is essential for survival but can paradoxically promote age-related diseases like cancer.
  • Centenarians exhibit genetic markers for better inflammation control, conferring cancer resistance.

Conclusions:

  • The pro-inflammatory state of aging is a potential mechanism connecting aging and cancer.
  • Centenarians possess a genetic profile offering resistance to cancer, characterized by an anti-inflammatory phenotype.
  • Reduced inflammatory response capacity in centenarians protects against inflammatory pathologies, including cancer.